Protein Details: Acid-sensing ion channel 3

Protein ID

ICDB_Pro_1663

Protein Name

Acid-sensing ion channel 3

Gene Name

ASIC3; ACCN3; SLNAC1; TNAC1

Organism

Homo sapiens (Human)

Length

531 amino acids

AlphaFoldDB

AF-Q9UHC3-F1-model_v4.pdb

Function

Cation channel with high affinity for sodium;which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic;damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

Sequence

MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 26: "Potassium ion selectivity and permeability"

Disease

Ovarian Endometrioid Adenofibroma and Pontocerebellar Hypoplasia;Type 16

Location

Expressed by sensory neurons. Strongly expressed in brain;spinal chord;lung;lymph nodes;kidney;pituitary;heart and testis.

DOI ID

10.1006/bbrc.1998.8483; 10.1016/s0014-5793(98)00916-8; 10.1046/j.1471-4159.1999.0720051.x; 10.1038/ng1285; 10.1074/jbc.m004114200; 10.1016/s0028-3908(01)00107-1; 10.1073/pnas.252782799; 10.1074/jbc.m405874200

RefSeq

NP_004760.1 [Q9UHC3-1]; NP_064717.1 [Q9UHC3-3]; NP_064718.1 [Q9UHC3-2]